Applied neuroscience research

Engineering the future of non-invasive brain therapy

We are a multidisciplinary research group that combines advanced neuroimaging and therapeutic ultrasound to develop diagnostic biomarkers and pioneering non-invasive therapeutic approaches for neurodegenerative disease.

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2018Established
2Core research fields
6Research lines
Who we are

An applied neuroscience lab at the intersection of imaging, ultrasound and AI

Bringing together engineers, physicists and computer scientists, we develop cutting-edge technological solutions to advance neuroengineering and applied neuroscience.

Non-invasive

Reaching deep brain structures without a single incision.

Data-driven

AI and large-scale data power our biomarkers and predictive models.

Translational

A direct link between scientific discovery and clinical reality.

Research

Two fields, six research lines

Our work spans the full arc of non-invasive neurotechnology.

Advanced Neuroimaging

01
Molecular PET imaging

FDOPA and FDG PET biomarkers of dopaminergic function.

02
Structural & diffusion MRI

Diffusion and quantitative MRI of brain microstructure.

03
AI biomarkers & modeling

ML and disease-progression models for Parkinson's disease.

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Therapeutic Ultrasound

04
HIFU Thermoablation

Precise, incision-free lesioning of deep brain targets.

05
Blood-Brain Barrier Opening

Ultrasound-enabled drug and gene delivery across the BBB.

06
Ultrasound Neuromodulation

Transcranial stimulation to map circuits and find targets.

Explore ultrasound →
Flagship project

D3-HIFU

A data-driven decision-support platform for MR-guided high-intensity focused ultrasound.

MR thermometry of a focused-ultrasound thermal lesion
Active · Funded July 2025

Making HIFU brain therapy data-driven

Pooling real-world data from nine centers and applying machine learning to optimize every stage of MR-guided HIFU.

MRgHIFU Machine Learning Decision Support 9 centers
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Lab news

Latest from the lab

Nigrostriatal pathway tractography
Publication2026

Mapping the nigrostriatal pathway in early Parkinson's

Our new Neurobiology of Disease paper mapping nigrostriatal degeneration with diffusion MRI.

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DREAM-ON-FUS timeline
Project17 Mar 2025

DREAM-ON-FUS Timeline: Key Milestones and Planning

The detailed timeline and milestones for our BBB-opening project.

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Winter School on Therapeutic Ultrasound
Lab News17 Mar 2025

NTUS Lab at the Winter School on Therapeutic Ultrasound

A week in the French Alps with leaders in therapeutic ultrasound.

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PhD defence
Lab News1 Feb 2025

Dr. Miguel López Aguirre Earns His PhD Cum Laude 🎓

A successful doctoral defence on nigrostriatal degeneration.

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Collaborate with us

Building the next generation of brain therapies

We partner with academia, clinicians and industry pioneers.

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